OPEN POSITIONS
Current Opportunities at the Brain Research Institute of the University Zurich
and the Institute for Neuroscience at ETH Zurich
PHD POSITION IN
NEUROEPIGENETICS
The Mansuy lab is looking for a PhD student to work on a project at the interface between neuroscience and epigenetics.
The project investigates the epigenetic mechanisms involved in the expression and the inheritance of traits or symptoms resulting from life experiences. It focuses on factors and mechanisms that modify the activity of the genome in relation to behavior and metabolism across generations in mice. The main goals are to identify the factors that link experiences in early life, particularly traumatic stress, to epigenetic alterations in the brain and germ cells, and assess their causal implication in symptoms resulting from exposure. The approach is multidisciplinary and uses a mouse model of postnatal trauma, organoids and cultured cells, genetics/epigenetics methods, in vivo analyses, mouse surgery, CRISPR tools for genome/epigenome editing, multiomic analyses (RNA-seq, ATAC-seq, bisulfite sequencing), and bioinformatics.
POSTDOCTORAL POSITION IN
CHROMATIN AND BIOLOGY
The Mansuy lab is looking for an experienced epigeneticist interested in chromatin remodeling.
The project aims at investigating the mechanisms underlying the impact of life experiences on the genome and epigenome in relation to brain functions and behavior across generations. The purpose is to examine the effects of exposure on genome sequence, structure and activity including retrotransposition and chromatin looping, and their inheritance in the germline and brain cells. The candidate should have solid theoretical and practical knowledge in genetics/epigenetics and chromatin biology, and some experience in advanced genome technologies and bioinformatics. The candidate should have an interest in exploring novel rules linking the environment to the genome and the epigenome, and in translational research relevant for human health and diseases. The new postdoc will join a pluridisciplinary team at the interface of epigenetics, neuroscience, reproductive biology and bioinformatics using an approach based on environmentally and genetically-modified mouse models. A strong team spirit, high scientific creativity and motivation are desired.
Women candidates are strongly encouraged to apply. This 3-5 years position is available in summer 2024 or anytime later.
MASTER'S POSITION IN NEUROEPIGENETICS
The Mansuy lab is looking for a Master student to work on a project at the interface between neuroscience and epigenetics. The project investigates the epigenetic mechanisms involved in the expression and the inheritance of traits or symptoms resulting from life experiences. It focuses on factors and mechanisms that modify the activity of the genome in relation to behavior and metabolism across generations in mice. The main goals are to identify the factors that link traumatic experiences in early life to epigenetic alterations in the brain and germ cells, and examine how they can be corrected and causally linked to the reversal of symptoms and health improvement.
The project is embedded in a research program on epigenetic inheritance conducted by the lab. It is based on a pluridisciplinary approach that uses a mouse model of trauma in combination with molecular and cell biology techniques, -omics approaches including transcriptomics, methylomics, metabolomics, etc, behavioral testing, and bioinformatics. Clinical analyses in trauma patients are also conducted.
The project is envisioned to be followed by a PhD.
MASTER'S POSITION IN
BIOINFORMATICS
The Mansuy lab is looking for a Master student to work on a project at the interface between computation and biology and aims to gain insight into the biological mechanisms of epigenetic inheritance by mining data from the literature. The purpose is to analyse multi-omics data including DNA methylome, transcriptome, chromatin structure, proteome and/or metabolome in mouse and rat models and/or humans using publically available and customized pipelines and algorithms. It also involves a part on software development and improvement for multi-omics data analysis. The student will join a team of bioinformaticians and biologists who work together on the generation and analyses of experimental data.
Programming in R/Python and knowledge of UNIX-like platform is required. Knowledge of Git and some experience in analyzing NGS data is advantageous. Applicants with research experience are particularly encouraged to apply. The position is available now for a minimum of 10 months. Applicants from biology, bioinformatics, mathematics, computer science, physics or any relevant interdisciplinary background are welcome.
INTERESTED IN A PHD OR POSTDOC?
GET IN TOUCH!
CONTACT
Prof. Isabelle Mansuy
ADDRESS
Winterthurerstrasse 190
8057 Zurich
Switzerland