CONSORTIA
Here you will find more information on all the (inter)national research projects the Mansuy lab is involved in.
STRESS
HMZ Flagship Project
Millions of people across all ages are affected by stress. Stress has long-term negative consequences on mental and physical health and is a strong risk factor for chronic conditions, particularly psychiatric and cardiovascular diseases. The prevalence of stress-induced diseases has become of major concern in the past years.
The STRESS project will develop a dynamic and radically innovative research program based on state-of-the-art methodologies to create a paradigm shift in the current thinking about stress-induced diseases and novel therapeutic approaches. Given its strategic importance, the HMZ STRESS project has been included in the University Medical Center Zurich (UMZH).
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EARLYCAUSE
Horizon 2020
Stress experienced in the early stages of life – from pregnancy to adolescence – is common and pervasive, affecting up to 75% of pregnant women (and the unborn baby) and nearly 50% of children, with long term consequences for development and health. The EarlyCause project will study the hypothesis that early life stress (ELS), a well-established risk factor for depressive, cardiovascular and metabolic disorders individually, is a cause of multi-morbidity in these disorders.
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FAMILY
Horizon Europe
The FAMILY consortium will systematically integrate the family context in the study of mental disorders. Families will be considered as an extra source of information beyond only individual information and allow the understanding and identification of the risk of transmission of mental illness from parents to offspring.
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HappyMums
Horizon Europe
HappyMums is designed to improve our understanding on the biological mechanisms underlying the development of depressive symptoms in pregnancy, and the efficacy of possible therapeutic interventions.
HappyMums will interrogate a large collection of cohorts with multiple biological, medical, clinical, socio-demographic and environmental and lifestyle data to identify the most important risk factors for depressive symptoms in pregnancy, but also possible moderators of the risk.
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EMPATHY
ERA-NET NEURON
Eating disorders are severe psychiatric conditions characterized by persistent disturbances in eating behavior that adversely affect physical and psychological health. The EMPATHY project investigates how maternal metabolic health, particularly exposure to a high-fat diet during pregnancy and lactation, may influence their offspring's brain development and their predisposition to eating disorders later in life. Using complementary approaches ranging from human cell cultures to animal models, as well as analyses of human milk, this research aims to elucidate how altered maternal metabolic states disrupt neural circuits that control feeding behavior.
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